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Bosulif (Bosutinib)

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Bosulif (Bosutinib Tablets) contains bosutinib, a second‑generation tyrosine kinase inhibitor that targets the BCR‑ABL fusion protein in Philadelphia chromosome–positive chronic myelogenous leukemia (CML). Designed for patients resistant or intolerant to prior TKIs, Bosulif slows disease progression and supports blood count recovery, administered orally in daily tablets under oncologist care.

Dose

100 MG400 MG500 MG

Pack Size

60 Tablet120 Tablet180 Tablet

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✅ Key Benefits

Targets BCR‑ABL kinase to control Philadelphia chromosome CML
Effective in patients intolerant or resistant to previous TKIs
Taken orally once or twice daily for convenience
May support improved hematologic and cytogenetic response
Used in both first-line and refractory treatment settings

🎯 How to Use

Starting dose: usually 500 mg once daily with food
Take with water; do not crush or chew tablets
Avoid grapefruit and grapefruit juice during therapy
Monitor blood counts, liver & kidney function periodically
Adjust dose based on side effects and lab values

⚠️ Precautions

Prescription-only oncology therapy; follow medical supervision strictly
Monitor for liver, cardiac and hematologic adverse effects
Avoid if severe hepatic impairment or known QT prolongation
Not advised during pregnancy or breastfeeding unless medically cleared
Discontinue and seek immediate care if symptoms like severe bleeding or irregular heartbeat occur

🤕 Possible Side Effects

Common: Diarrhea, nausea, fatigue, rash
Occasional: Elevated liver enzymes, myelosuppression
Rare but serious: Hepatotoxicity, bleeding, QT prolongation—medical evaluation necessary if symptoms appear

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❓ Frequently Asked Questions (FAQs)

Q. What is Bosulif used to treat?
A. It’s prescribed for Philadelphia chromosome–positive CML, especially for patients resistant or intolerant to other TKIs.

Q. How long until effectiveness is seen?
A. Hematologic improvement often appears within weeks; cytogenetic response may take 3–6 months.

Q. Can food affect absorption?
A. Bosulif should be taken with food; avoid grapefruit to prevent drug interactions.

Q. Are blood tests needed during treatment?
A. Yes—frequent monitoring of CBC, liver enzymes, and ECG (if cardiac risks exist) is essential.