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CA‑Atra (All‑Trans Retinoic Acid)

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CA‑Atra (All‑Trans Retinoic Acid Tablets) contains all-trans retinoic acid (ATRA), a differentiation therapy used for acute promyelocytic leukemia (APL). ATRA induces malignant promyelocytes to differentiate into mature cells, helping induce remission. Used under oncologist supervision, CA‑Atra forms a key part of APL induction regimens in combination or alone.

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✅ Key Benefits

Promotes differentiation of leukemic promyelocytes in APL
Shown to induce remission in acute promyelocytic leukemia
Oral administration allows outpatient-based therapy support
Integral component of APL treatment protocols
Well‑studied and core to differentiation therapy under clinical guidance

🎯 How to Use

Adults: Typically 45 mg/m² daily in divided doses as per regimen
Swallow tablets with water; do not crush or chew
Take at consistent time each day
Monitor blood counts, liver and kidney function, and cardiac status
Store in a cool, dry place—keep out of children’s reach

⚠️ Precautions

Prescription differentiation therapy—use under specialist care
Monitor for differentiation syndrome, liver function, and triglycerides
Avoid pregnancy and use effective contraception during treatment
Discontinue and seek medical care if fever, breathing difficulties, or rapid weight gain occurs
Manage drug interactions, particularly with anticoagulants and steroids

🤕 Possible Side Effects

Common: Headache, dry skin, elevated liver enzymes, hyperlipidemia
Occasional: Fever, conjunctivitis, joint pain
Rare but serious: Differentiation syndrome, pseudotumor cerebri, hepatic toxicity—seek immediate care if experienced

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❓ Frequently Asked Questions (FAQs)

Q. What is CA‑Atra used for?
A. CA‑Atra is used to treat acute promyelocytic leukemia by inducing leukemic cell differentiation.

Q. How is it taken?
A. Typically 45 mg/m² daily in divided doses with treatment protocols guided by specialists.

Q. Is monitoring required?
A. Yes—blood counts, liver/kidney function, cardiac health, and signs of differentiation syndrome must be closely observed.

Q. Can it be used during pregnancy?
A. No—contraindicated in pregnancy; strict contraception required during treatment.