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Isentress 400 mg (Raltegravir)

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Isentress 400 mg (Raltegravir Tablets) contains raltegravir, a first-generation integrase strand transfer inhibitor designed to block HIV‑1 integration into host DNA. With once or twice daily oral dosing (depending on regimen), Isentress reduces viral replication, supports immune reconstitution, and presents high tolerability. It’s suitable for both treatment-naïve and experienced patients under medical supervision.

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✅ Key Benefits

Blocks HIV‑1 integrase to prevent viral DNA integration
Rapidly decreases viral load and supports CD4 recovery
Flexible dosing—once or twice daily per regimen
High barrier to resistance and good safety profile
Widely used in first-line and salvage ART regimens

🎯 How to Use

Adults: 400 mg twice daily, or once daily when used with certain agents like ritonavir-boosted protease inhibitors
Take with or without food; maintain consistent timing
Monitor viral load, liver and kidney function regularly
Swallow tablets whole; do not crush or chew
Store in a cool, dry environment away from children

⚠️ Precautions

Prescription-only ARV; use under clinician guidance
Monitor for neuropsychiatric symptoms, liver function, and muscle effects
Caution in pregnancy or breastfeeding—consult healthcare provider
Avoid coadministration with polyvalent cations (e.g. antacids or supplements) unless spaced dosing
Discontinue and report if severe rash, muscle pain, or psychiatric symptoms occur

🤕 Possible Side Effects

Common: Sleep disturbances, headache, nausea, fatigue
Occasional: Elevated liver enzymes, joint pain, depression
Rare but serious: Rhabdomyolysis, severe hypersensitivity, immune reconstitution inflammatory syndrome—seek medical attention if present

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❓ Frequently Asked Questions (FAQs)

Q. What is Isentress 400 mg used for?
A. It’s an HIV integrase inhibitor used in combined ART to suppress viral replication and support immune health.

Q. How soon does it reduce viral load?
A. Viral load can decline in the first weeks; full viral suppression typically achieved within months.

Q. Can children or pregnant individuals use it?
A. Pediatric formulations exist; use during pregnancy only with medical supervision.

Q. Do I need lab tests while taking Isentress?
A. Yes—viral load, liver and renal function monitoring are essential.