Nublexa 40 mg (Regorafenib)

✅ Key Benefits

• Inhibits VEGFR, PDGFR, FGFR, and oncogenic kinases to hinder tumor growth

• Approved for colorectal, liver, and GIST cancers post‑first‑line therapy

• Oral dosing supports outpatient management

• Demonstrated survival benefit in refractory disease

• Administered via well‑established oncology protocols

🎯 How to Use

• Adults: 40 mg tablets; typical starting dose schedules 40 mg to 160 mg once daily with food for 21 days, followed by 7‑day break—titrated per tolerance

• Swallow tablets whole—do not crush or chew

• Monitor liver function, blood pressure, and ECG during cycles

• Store in a cool, dry place away from children’s reach

⚠️ Precautions

• Prescription-only medication—use under oncology supervision

• Monitor hepatotoxicity, dermatologic reactions, and hypertension

• Avoid use during pregnancy or breastfeeding

• Adjust dosing for liver impairment

• Discontinue and seek immediate care if severe bleeding, liver toxicity, or hand–foot syndrome occur

🤕 Possible Side Effects

• Common: Fatigue, hypertension, hand–foot skin reaction, diarrhea, decreased appetite

• Occasional: Weight loss, mucositis, nausea, rash

• Rare but serious: GI perforation, cardiac ischemia, severe hepatotoxicity—seek urgent medical attention if present

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❓ Frequently Asked Questions (FAQs)

Q. What is Nublexa used for?
A. Nublexa is used for metastatic colorectal, hepatocellular carcinoma, and GIST after failure of previous therapy by targeting tumor kinases.

Q. How is dosing structured?
A. Taken in cycles (typically 40–160 mg daily for 21 days on, 7 days off), dose adjusted by oncologist based on tolerance.

Q. Is monitoring required during treatment?
A. Yes—monitor liver enzymes, blood pressure, ECG, skin for reactions, and symptoms of toxicity.

Q. Can Nublexa be used during pregnancy?
A. No—contraindicated during pregnancy and breastfeeding; effective contraception advised.