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Resihance (Regorafenib)

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Resihance (Regorafenib Tablets) contains regorafenib, an oral multikinase inhibitor targeting tumor angiogenesis, oncogenesis, and tumor microenvironment. It’s approved for metastatic colorectal cancer, hepatocellular carcinoma, and gastrointestinal stromal tumors (GIST) after prior therapy failure. Taken once daily for three weeks on/one week off in cycles under oncologist guidance.

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✅ Key Benefits

Inhibits VEGFR, PDGFR, FGFR, and oncogenic kinases to slow tumor growth
Approved for use in colorectal cancer, liver cancer, and GIST
Oral dosing offers outpatient therapy convenience
Demonstrated survival benefit in advanced disease after prior treatments
Used per oncology protocols under specialist supervision

🎯 How to Use

Adults: 160 mg (four 40 mg tablets) once daily with low-fat breakfast for 21 days, followed by 7-day break
Swallow tablets whole; do not crush or chew
Regular monitoring: blood pressure, liver function, thyroid function, and ECG
Store in a cool, dry place—keep out of children’s reach

⚠️ Precautions

Prescription-only oncology drug—use only under specialist care
Monitor blood pressure, liver enzymes, thyroid levels, and ECGs
Not recommended during pregnancy or breastfeeding
Avoid use with known strong CYP3A4 inducers/inhibitors
Discontinue and seek medical advice if severe bleeding, hypertension, liver toxicity, or hand–foot skin reactions occur

🤕 Possible Side Effects

Common: Fatigue, hypertension, hand–foot skin reactions, diarrhea, decreased appetite
Occasional: Weight loss, hepatotoxicity, mucositis, skin rash
Rare but serious: GI perforation, cardiac ischemia, liver failure, hemorrhage—seek immediate medical attention if symptoms occur

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❓ Frequently Asked Questions (FAQs)

Q. What is Resihance used for?
A. Resihance treats metastatic colorectal, hepatocellular carcinoma, and gastrointestinal stromal tumors after prior therapy failure.

Q. How is the treatment cycle structured?
A. Taken daily for 21 days, followed by 7 days off, repeated in cycles as directed by your oncologist.

Q. What monitoring is required?
A. Blood pressure, liver and thyroid function, ECGs, and for skin effects, gastrointestinal symptoms, or bleeding.

Q. Can it be used during pregnancy?
A. No—pregnant or breastfeeding individuals should avoid regorafenib due to high fetal risk.