Votrient (Pazopanib)

✅ Key Benefits

• Inhibits VEGFR, PDGFR, and c‑Kit to reduce tumor blood supply

• Approved for kidney cancer and soft tissue sarcoma

• Oral dosing for outpatient convenience

• Proven to extend progression‑free survival

• Manageable safety profile with routine monitoring

🎯 How to Use

• Adults: 800 mg once daily on empty stomach (1 hour before or 2 hours after food)

• Swallow tablets whole—do not crush or chew

• Take at the same time every day

• Monitor liver function, blood pressure, thyroid function, and cardiac status

• Store in a cool, dry place, away from children

⚠️ Precautions

• Prescription-only targeted therapy—use under specialist care

• Monitor hepatotoxicity, hypertension, QT prolongation, and thyroid function

• Avoid in pregnancy or breastfeeding—use effective contraception

• Adjust dose for moderate to severe hepatic impairment

• Discontinue and seek medical care if severe liver injury, bleeding, cardiac issues, or GI perforation occurs

🤕 Possible Side Effects

• Common: Diarrhea, hypertension, nausea, hair color change, liver enzyme elevation

• Occasional: Fatigue, anorexia, vomiting, hand–foot syndrome

• Rare but serious: Hepatic failure, QT prolongation, severe bleeding—seek immediate medical care if these occur

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❓ Frequently Asked Questions (FAQs)

Q. What is Votrient used for?
A. Votrient treats advanced renal cell carcinoma and soft tissue sarcoma by inhibiting tumour angiogenesis.

Q. How should I take it?
A. 800 mg once daily on an empty stomach—consistently at the same time, as directed.

Q. Is monitoring required during treatment?
A. Yes—monitor liver tests, blood pressure, thyroid and cardiac function regularly.

Q. Can it be used during pregnancy?
A. No—it’s contraindicated; effective contraception is required during use.